Teratogenicity of drugs used in dermatological diseases

Drugs Used in Dermatological Disorders

Teratogenicity of Antiepileptic Drugs

Objective Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies. Methods This is a retrospective study of malformations in child...

Dermatological pharmacology: systemic drugs

In recent years there has been an evolution in the systemic therapy of skin disease, in particular immunosuppressive agents, retinoids and, most lately, biological drugs and new classes of drugs for advanced skin cancer. Developments in drug monitoring include measurement of thiopurine methyl transferase enzyme activity before prescribing azathioprine, to screen for patients at risk of severe b...

Comparative Teratogenicity of Alcohol and Other Drugs

The National Institute on Drug Abuse (NIDA) conducted a national household survey of drug use in 1990, completing interviews with 9,259 people. Of all women surveyed, 78.7 percent reported they had drunk alcohol in their lifetime (NIDA 1991a). Sixty­one percent drank in the past year, and 44.1 percent drank in the past month. Women were generally light drinkers: 19 percent drank less often than...

Therapeutic Apheresis in Dermatological Diseases

Since the mid-1970s, membrane modules became available and plasma separation techniques have gained importance. Therapeutic apheresis (TA) has been successfully introduced in a variety of autoantibody-mediated diseases. In dermatology, TA is increasingly applied as a support treatment for severe and/or refractory autoimmune bullous diseases. All autoimmune disease are characterized by autoantib...